Darovasertib

Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2].

Product Specifications

CAS Number

[1874276-76-2]

Product Name Alternative

LXS196; IDE196

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LXS196.html

Purity

99.18

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1

Molecular Formula

C22H23F3N8O

Molecular Weight

472.47

Precautions

H302, H315, H319

References & Citations

[1]Protein Kinase C Inhibitor LXS196|[2]US20180179181.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

PKCα; PKCθ

Available Sizes

Curated Selection

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