L-Leucinol
L-Leucinol ((+) -Leucinol) is a competitive aminopeptidase inhibitor with Ki value of 17 μM. L-Leucinol is commonly used in in vitro enzymatic experiments. L-Leucinol can be used for synthesizing peptides[1][2].
Product Specifications
CAS Number
[7533-40-6]
Product Name Alternative
(+) -Leucinol
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-leucinol.html
Concentration
10mM
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)C[C@H](N)CO
Molecular Formula
C6H15NO
Molecular Weight
117.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Bienvenue DL, et al. Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinethiol: kinetic and spectroscopic characterization of a slow, tight-binding inhibitor-enzyme complex. J Inorg Biochem. 2000 Jan 15;78 (1) :43-54.|[2]Casagrande N, et al. Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids. Int J Mol Sci. 2021 Aug 4;22 (16) :8362.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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