(1R,3S) -Compound E
(1R,3S) -Compound E is an isomer of Compound E and can be used as a control compound in experiments. It serves as a γ-secretase inhibitor. The IC50 values of Compound E for inhibiting β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage are 0.24, 0.37, and 0.32 nM, respectively.
Product Specifications
CAS Number
504428-17-5
Field of Research
Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
N (C ([C@H] (NC (CC1=CC (F) =CC (F) =C1) =O) C) =O) [C@H]2N=C (C=3C (N (C) C2=O) =CC=CC3) C4=CC=CC=C4
Molecular Formula
C27H24F2N4O3
Molecular Weight
490.50
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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