TWEAK-Fn14-IN-1

TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent TWEAK-Fn14 inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a KD of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects[1].

Product Specifications

CAS Number

[951612-19-4]

Product Name Alternative

ABR-215757; ABR 25757,ABR-215757-d5; ABR 25757-d13

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tweak-fn14-in-1.html

Purity

99.62

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1CCSCC1)C2=CN(N=N2)C3=CC=CC(Cl)=C3

Molecular Formula

C13H13ClN4OS

Molecular Weight

308.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Tran N, et al. Compositions and methods of screening for compounds that modulate activity at a tweak binding site on a crd of fn14. US20160146784A1