TWEAK-Fn14-IN-1
TWEAK-Fn14-IN-1 (Compound L524-0366) is a specific dose-dependent TWEAK-Fn14 inhibitor. TWEAK-Fn14-IN-1 binds specifically to the Fn14 surface with a KD of 7.12 μM. TWEAK-Fn14-IN-1 inhibits TWEAK induced glioma cell migration without any potential cytotoxic effects[1].
Product Specifications
CAS Number
[951612-19-4]
Product Name Alternative
ABR-215757; ABR 25757,ABR-215757-d5; ABR 25757-d13
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tweak-fn14-in-1.html
Purity
99.62
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N1CCSCC1)C2=CN(N=N2)C3=CC=CC(Cl)=C3
Molecular Formula
C13H13ClN4OS
Molecular Weight
308.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Tran N, et al. Compositions and methods of screening for compounds that modulate activity at a tweak binding site on a crd of fn14. US20160146784A1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF12A/TWEAK
Available Sizes
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