MMAD-d8
MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
Product Specifications
Product Name Alternative
Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8
UNSPSC
12352005
Target
ADC Payload; Microtubule/Tubulin
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
Molecular Formula
C41H58D8N6O6S
Molecular Weight
779.11
References & Citations
[1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8 (2) :114-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
Frequently Asked Questions
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