Hydroxy-α-sanshool (Standard)

Hydroxy-α-sanshool (Standard) is the analytical standard of Hydroxy-α-sanshool. This product is intended for research and analytical applications. Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research[1][2].

Product Specifications

CAS Number

[83883-10-7]

UNSPSC

12352211

Target

Endogenous Metabolite; Reference Standards; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydroxy-α-sanshool-standard.html

Smiles

C/C=C/C=C/C=C\CC/C=C/C(NCC(C)(O)C)=O

Molecular Formula

C16H25NO2

Molecular Weight

263.38

References & Citations

[1]Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157 (8) :1398-409.|[2]Koo JY, et al. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci. 2007 Sep;26 (5) :1139-47.