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CDK5-IN-3

CDK5-IN-3 (compound 11) is a potent CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) [1].

Product Specifications

CAS Number

2639542-32-6

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cdk5-in-3.html

Purity

99.49

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4

Molecular Formula

C22H26N4O

Molecular Weight

362.47

References & Citations

[1]Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65 (4) :3575-3596.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK2; CDK5

Available Sizes

Frequently Asked Questions

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