CDK5-IN-3
CDK5-IN-3 (compound 11) is a potent CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) [1].
Product Specifications
CAS Number
[2639542-32-6]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cdk5-in-3.html
Purity
99.49
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4
Molecular Formula
C22H26N4O
Molecular Weight
362.47
References & Citations
[1]Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65 (4) :3575-3596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5
Available Sizes
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