AMPKα2 rabbit pAb
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
5563
UniProt
P54646
Cellular Locus
Cytoplasm. Nucleus. In response to stress, recruited by p53/TP53 to specific promoters..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of AMPKα2
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Dilution
WB: 1:1000-2000
Molecular Weight
62kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20835-1.pdf
Observed Molecular Weight
62 kD
Subcellular Location
Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
Other Product Names
Gene ID (Human)
5563
SwissProt (Human)
P54646
Available Sizes
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