AMPKα2 rabbit pAb
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
UniProt
P54646
Swiss Prot
P54646
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of AMPKα2
Target
AMPKα2
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Dilution
WB: 1:1000-2000
Buffer
-20°C/1 year
Molecular Weight
62kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
62kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
Other Product Names
Gene ID (Human)
5563
Available Sizes
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