Piperonylic acid

Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities[1][2][3][4].

Product Specifications

CAS Number

[94-53-1]

Product Name Alternative

2H-1,3-benzodioxole-5-carboxylic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450; EGFR; IGF-1R; Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Others

Assay Protocol

https://www.medchemexpress.com/piperonylic-acid.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(OCO2)C2=C1)O

Molecular Formula

C8H6O4

Molecular Weight

166.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Schalk M, et al, Werck-Reichhart D. Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway. Plant Physiol. 1998;118 (1) :209‐218.|[2]Lee D, et al. Piperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR) . Sci Rep. 2018 Jan 9;8 (1) :162. |[3]Zarai, Zied, et al. "Antioxidant and antimicrobial activities of various solvent extracts, piperine and piperic acid from Piper nigrum." Lwt-Food science and technology 50.2 (2013) : 634-641. |[4]Moreira KG, et al. Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition. PLoS One. 2021 Oct 26;16 (10) :e0259134.