(S) -Padsevonil

(S) -Padsevonil is the S-enantiomer of Padsevonil. Padsevonil (UCB0942) is a potent antiepileptic agent that selectively targets both presynaptic and postsynaptic sites. It binds with high affinity to synaptic vesicle protein 2 (SV2) and acts as a positive allosteric modulator and partial agonist of GABAAR, showing greater efficacy on receptors containing α1 and α5 subunits. Padsevonil demonstrates antiepileptic effects in various rodent models.