(Rac) -Vepdegestrant
(Rac) -Vepdegestrant is an isomer of Vepdegestrant. Vepdegestrant ((Rac) -ARV-471) is an orally active estrogen receptor PROTAC degrader used against breast cancer. It is a heterobifunctional molecule that facilitates the interaction between estrogen receptor α and the intracellular E3 ligase complex. Vepdegestrant induces ubiquitination and subsequent degradation of the estrogen receptor via the proteasome, effectively degrading ER in ER-positive breast cancer cell lines with a DC50 value of approximately 2 nM.
Product Specifications
CAS Number
2229711-08-2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
OC=1C=C2C ([C@H] ([C@H] (CC2) C3=CC=CC=C3) C4=CC=C (C=C4) N5CCC (CN6CCN (CC6) C=7C=C8C (=CC7) C (=O) N (C8) C9C (=O) NC (=O) CC9) CC5) =CC1
Molecular Formula
C45H49N5O4
Molecular Weight
723.90
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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