PF-07202954

PF-07202954 is a weakly basic DGAT2 inhibitor with an IC50 of 10 nM for human DGAT2. PF-07202954 lowers liver triglyceride content in a Western-diet-fed rat model[1].

Product Specifications

CAS Number

[2639372-47-5]

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pf-07202954.html

Purity

98.82

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CN=C(C2=CC(OC3=NC=CC=C3OCC)=CN=C2)N=C1)N[C@@H]4CNC[C@@H](F)C4

Molecular Formula

C22H23FN6O3

Molecular Weight

438.45

References & Citations

[1]Kevin J Filipski, et al. Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life. ACS Med Chem Lett. 2023 Oct 2;14 (10) :1427-1433.