(S, R, S) -MI-1061
(S, R, S) -MI-1061 is an isomer of MI-1061. It serves as a precursor for synthesizing Antibody-Drug Conjugates (ADCs) . MI-1061 acts as a potent, orally bioavailable, and chemically stable inhibitor of MDM2 (MDM2-p53 interaction) with IC50=4.4 nM and Ki=0.16 nM. This compound activates p53 and induces apoptosis in murine SJSA-1 xenograft tissues, exhibiting antitumor properties.
Product Specifications
CAS Number
1410738-90-7
Field of Research
Cell Biology
Smiles
O=C1[C@]2 (C3 (N[C@H] (C (NC4=CC=C (C (O) =O) C=C4) =O) [C@H]2C5=C (F) C (Cl) =CC=C5) CCCCC3) C=6C (N1) =CC (Cl) =CC6
Molecular Formula
C30H26Cl2FN3O4
Molecular Weight
582.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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