Etidronic acid (disodium)

Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4].

Product Specifications

CAS Number

[7414-83-7]

Product Name Alternative

Etidronate (disodium) ; HEDPA (disodium) ; HEDP (disodium)

UNSPSC

12352211

Hazard Statement

H302

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/etidronic-acid-disodium.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

OC(P(O)(O[Na])=O)(P(O)(O[Na])=O)C

Molecular Formula

C2H6Na2O7P2

Molecular Weight

249.99

Precautions

H302

References & Citations

[1]Dunn CJ, et al. Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging. 1994 Dec;5 (6) :446-74. |[2]Ariyoshi T, et al. Effect of etidronic acid on arterial calcification in dialysis patients. Clin Drug Investig. 2006;26 (4) :215-22. |[3]Zhou Y, et al. Cytotoxicity of etidronic acid to human breast cancer cells. Ethn Dis. 2008 Spring;18 (2 Suppl 2) :S2-87-92. |[4]Zhu S, et al. In-Depth Study of Heavy Metal Removal by an Etidronic Acid-Functionalized Layered Double Hydroxide. ACS Appl Mater Interfaces. 2022 Feb 9;14 (5) :7450-7463. |[5]Kameda T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997 Aug 18;186 (4) :489-95.