PF-06409577

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

Product Specifications

CAS Number

[1467057-23-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PF-06409577.html

Purity

99.83

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O

Molecular Formula

C19H16ClNO3

Molecular Weight

341.79

Precautions

H315, H319, H335

References & Citations

[1]Cameron KO, et al. Discovery and Preclinical Characterization of 6-Chloro-5-[4- (1-hydroxycyclobutyl) phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J Med Chem. 2016 Sep 8;59 (17) :8068-81.|[2]Salatto CT, et al. Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J Pharmacol Exp Ther. 2017 May;361 (2) :303-311.