PF-06409577
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
Product Specifications
CAS Number
1467057-23-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-06409577.html
Purity
99.83
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O
Molecular Formula
C19H16ClNO3
Molecular Weight
341.79
Precautions
H315, H319, H335
References & Citations
[1]Cameron KO, et al. Discovery and Preclinical Characterization of 6-Chloro-5-[4- (1-hydroxycyclobutyl) phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J Med Chem. 2016 Sep 8;59 (17) :8068-81.|[2]Salatto CT, et al. Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J Pharmacol Exp Ther. 2017 May;361 (2) :303-311.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
AMPK α1β1γ1
Available Sizes
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