Hyrtiosal
Hyrtiosal, discovered in the marine sponge Hyrtios erectus, is an inhibitor of HIV-1 integrase (HIV-1IN) at the N-terminal domain (NTD), exhibiting an IC50 value of 9.60-0.86 μM. It binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1IN, thereby preventing the integration of HIV-1 viral DNA with the enzyme and disrupting the formation of the HIV-1 pre-integration complex. Hyrtiosal holds potential for research as an anti-HIV agent.
Product Specifications
CAS Number
138355-07-4
Field of Research
Infectious Disease & Virology, Protein Biochemistry
Smiles
C[C@]12[C@@] ([C@]3 (C) [C@@] (CC1) (C (C) (C) CCC3) [H]) (C[C@@] (C=O) (C) [C@H]2C[C@H] (O) C=4C=COC4) [H]
Molecular Formula
C25H38O3
Molecular Weight
386.57
Storage Conditions
-20°C
Notes
For research use only.
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