NIR-BG2
NIR-BG2 is a near-infrared fluorescent probe that targets senescence-associated β-galactosidase (SA-β-Gal) . Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis, releasing an electrophilic methylquinone that covalently binds to surrounding proteins for in situ labeling, enhancing the fluorescence signal 16-fold at 709 nm. NIR-BG2 holds potential for in vivo imaging studies of cellular senescence.
Product Specifications
CAS Number
3036456-18-2
Field of Research
Cell Biology, Metabolism Research
Smiles
C (CC) [N+]=1C=2C (C (C) (C) C1/C=C/C3=C4C (=CC=5C (O4) =CC (OCC6=CC=C (O[C@@H]7O[C@H] (CO) [C@H] (O) [C@H] (O) [C@H]7O) C=C6) =C (C (F) F) C5) CCC3) =CC=CC2
Molecular Formula
C42H46F2NO8
Molecular Weight
730.81
Storage Conditions
-20°C
Notes
For research use only.
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