CJ28

CJ28 is a cortisol biosynthesis inhibitor. In human adrenocortical carcinoma cell models, it significantly reduces cortisol production under both basal and stimulated conditions. The mechanism of action of CJ28 is primarily associated with the inhibition of the steroidogenesis pathway and de novo cholesterol biosynthesis, thereby reducing the supply of cortisol precursors and downregulating hormone synthesis levels.