9-Methylstreptimidone

9-Methylstreptimidone (AntibioticTS 885; NSC 248958) is a microbial metabolite initially isolated from Streptomyces S-885, known for its antifungal and antiviral properties. It is effective against various fungi, such as S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus, with a MIC of 4-20 μg/mL. Additionally, it shows in vitro antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) with a MIC of 0.02 μg/mL. Administering 9-Methylstreptimidone before infection can increase survival rates in mouse models infected with influenza A2 (H2N2) or Candida albicans.