A2AAR antagonist 2

3′-Methoxyfurano[4′′,5′′:3,4]chalcone (Compound 2) is a selective A2AAR antagonist with an IC50 of 33.5 nM, indicating it has a high affinity. This compound is a natural product that can be extracted from the skins of Allium cepa L. Additionally, 3′-Methoxyfurano[4′′,5′′:3,4]chalcone is capable of promoting T cell activation and is useful in cancer immunology research.