SAR107375-d11 (Tartrate)
SAR107375-d11 (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively[1][2].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Thrombin
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Smiles
CC1=C(N2CCCC2=O)C=CC=C1S(=O)(N[C@H](C(N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])[2H])C([2H])([2H])C3([2H])[2H])=O)CNC(C4=CC=C(S4)Cl)=O)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O
Molecular Formula
C28H25D11ClN5O11S2
Molecular Weight
729.26
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Jerome Meneyrol, et al. 5-Chlorothiophene-2-carboxylic acid [ (S) -2-[2-methyl-3- (2-oxopyrrolidin-1-yl) benzenesulfonylamino]-3- (4-methylpiperazin-1-yl) -3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J Med Chem. 2013 Dec 12;56 (23) :9441-56.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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