REV7/REV3L-IN-1
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1].
Product Specifications
CAS Number
[1979192-13-6]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rev7-rev3l-in-1.html
Purity
99.14
Solubility
DMSO : 7.14 mg/mL (ultrasonic)
Smiles
O=C(C)N1CCC(CN2C=NC(SC=C3C4=CC=C(C)O4)=C3C2=O)CC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
References & Citations
[1]Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24 (18) :4339-4346.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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