Tyrphostin A1 (Highly Pure)

<strong>Tyrphostin A1 (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2012407_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 184.2 g/mol_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Tyrphostin 1, (4-Methoxybenzylidene)malononitrile_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Du C, Bright JJ, Sriram S. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice J Neuroimmunol. 2001 Mar 1;114(1-2):69-79._x000D_ 2: Bright JJ, Du C, Sriram S. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis J Immunol. 1999 May 15;162(10):6255-62._x000D_ 3: Dickenson JM, Hill SJ. Potentiation of adenosine A1 receptor-mediated inositol phospholipid hydrolysis by tyrosine kinase inhibitors in CHO cells Br J Pharmacol. 1998 Nov;125(5):1049-57._x000D_ 4: Ogura T, Imanishi S, Shibamoto T. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes Jpn J Pharmacol. 2001 Nov;87(3):235-9._x000D_ 5: Andreis PG, Neri G, Tortorella C, Gottardo L, Nussdorfer GG. Tyrphostin-23 enhances steroid-hormone secretion from dispersed human and rat adrenocrotical cells Endocr Res. 2000 Aug;26(3):319-32._x000D_ 6: Ramdas L, Obeyesekere NU, McMurray JS, Gallick GE, Seifert WE Jr, Budde RJ. A tyrphostin-derived inhibitor of protein tyrosine kinases: isolation and characterization Arch Biochem Biophys. 1995 Nov 10;323(2):237-42._x000D_ 7: Faaland CA, Mermelstein FH, Hayashi J, Laskin JD. Rapid uptake of tyrphostin into A431 human epidermoid cells is followed by delayed inhibition of epidermal growth factor (EGF)-stimulated EGF receptor tyrosine kinase activity Mol Cell Biol. 1991 May;11(5):2697-703._x000D_ 8: Blumrich EM, Kadam R, Dringen R. The Protein Tyrosine Kinase Inhibitor Tyrphostin 23 Strongly Accelerates Glycolytic Lactate Production in Cultured Primary Astrocytes Neurochem Res. 2016 Oct;41(10):2607-2618._x000D_ 9: Tan CM, Xenoyannis S, Feldman RD. Oxidant stress enhances adenylyl cyclase activation Circ Res. 1995 Oct;77(4):710-7._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/19139916">10: Missan S, Qi J, Crack J, McDonald TF, Linsdell P. Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase Pflugers Arch. 2009 Jul;458(3):471-80. </a>_x000D_ _x000D_ <strong>Products Related to Tyrphostin A1 (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Chemicals/"> Chemicals</a>