MAO-B-IN-48

MAO-B-IN-48 is a selective inhibitor of MAO-B with an IC50 of 0.09 μM and Ki of 0.02 μM. It also demonstrates inhibitory activity against hBChE (IC50= 1.10 μM, Ki= 0.43 μM) and AChE (IC50= 0.56 μM, Ki= 0.14 μM) . MAO-B-IN-48 disrupts the self-induced aggregation of toxic β-amyloid peptides and exhibits antioxidant properties, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. This compound is applicable in Alzheimer’s disease (AD) research.