SMI-10B13
SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 μM. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.
Product Specifications
CAS Number
2502294-68-8
Field of Research
Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (O) C=CC=1OC (C=2C=CC=3C=CNC3C2) =C (C1) C=4C=CC=5C=CNC5C4
Molecular Formula
C23H16N2O3
Molecular Weight
368.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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