HI042
HI042 is an FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing an IC50 value of 0.62 μM for MOLM-13 cells, 0.33 μM for MV4-11 cells, and 0.89 μM for OCI-AML3 cells. It selectively reduces the survival rate of FLT3-internal tandem duplication (FLT3-ITD) positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes colony-forming ability. HI042 is applicable for acute myeloid leukemia (AML) research.
Product Specifications
CAS Number
898168-15-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C (C=CC=1C=CC=CC1) NN=CC=2SC (=CC2) N (=O) =O
Molecular Formula
C14H11N3O3S
Molecular Weight
301.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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