EVT0185
EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. In the liver, it is converted by SLC27A2 into a CoA thioester, which interacts with the CoA binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. It mimics the immune and antitumor effects seen with ACLY gene deletion. Additionally, EVT0185 elevates levels of tumor-infiltrating B cells and the chemokine CXCL13. It is applicable in cancer research, including hepatocellular carcinoma (HCC) .
Product Specifications
CAS Number
2588489-03-4
Field of Research
Metabolism Research
Smiles
O=C (O) C (C) (C) CCCCC1=CC=C (C=C1) CCCCC (C (=O) O) (C) C
Molecular Formula
C22H34O4
Molecular Weight
362.50
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6472832-01 0.1 mL
DOK2, CT (Docking Protein 2, Downstream Of Tyrosine Kinase 2, p56(dok-2)) (MaxLight 750)
Sign In for Pricing
View Details MBS6472832-02 5x 0.1 mL
DOK2, CT (Docking Protein 2, Downstream Of Tyrosine Kinase 2, p56(dok-2)) (MaxLight 750)
Sign In for Pricing
View Details 
302598-ML650 100 µL
NFE4 (Transcription Factor NF-E4, NFE4) (MaxLight 650) discontinued
Sign In for Pricing
View Details 