JP-2-196 hydrochloride

JP-2-196 hydrochloride is a covalent molecular glue degrader that specifically targets RNF126. It facilitates the formation of a ternary complex between RNF126 and target proteins (e.g., BRD4, AR-V7), promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride is being explored for potential applications in cancer research, such as prostate cancer and leukemia.