PNR-3-80
PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
Product Specifications
CAS Number
1424353-63-8
Field of Research
Cell Biology
Smiles
O=C1NC (=S) NC (=O) C1=CC2=CN (C (=O) C=3C=CC=4C=CC=CC4C3) C=5C=CC (Cl) =CC25
Molecular Formula
C24H14ClN3O3S
Molecular Weight
459.90
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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