IL-6-IN-2
IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compound's binding free energy (∆G) is −36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.
Product Specifications
CAS Number
296790-70-0
Field of Research
Immunology & Inflammation
Smiles
OC1=C (C (=NN1C=2C=CC=CC2) C) C (C=3OC (=CC3) C) C4=C (O) N (N=C4C) C=5C=CC=CC5
Molecular Formula
C26H24N4O3
Molecular Weight
440.49
Storage Conditions
-20°C
Notes
For research use only.
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