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JAK1-IN-17

JAK1-IN-17 (Compound 31) is a highly selective JAK1 inhibitor with a Ki of 1.9 nM. It exhibits low whole blood migration, allowing it to maintain effective pharmacological activity in whole blood. JAK1-IN-17 is also a nitrile-containing compound that provides stable but weak reversible inhibition of CYP3A4 using a midazolam probe (IC50= 7.9 μM) . This compound is applicable in cancer research.

Product Specifications

CAS Number

1315490-71-1

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Smiles

[C@H] (C) (O) C=1N (C2=C3C (NC=C2N1) =NC=C3) [C@@H]4CC[C@@H] (C#N) CC4

Molecular Formula

C17H19N5O

Molecular Weight

309.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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