HIV-1 inhibitor-6
Product Specifications
UNSPSC Description
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM[1].
Target Antigen
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-6.html
Smiles
O=C(C1=CN(C)C=CC1=O)NC2=NSC3=C2C=C([N+]([O-])=O)C=C3
Molecular Weight
330.32
References & Citations
[1]Peter K Cheung, et al. A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing. J Med Chem. 2016 Mar 10;59(5):1869-79.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134851/HIV-1-inhibitor-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134851/HIV-1-inhibitor-6-SDS-MedChemExpress.pdf
CAS Number
1821309-39-0
Available Sizes
Curated Selection
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