PROTAC Bcl-xL degrader-4
PROTACBcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader with significant antitumor activity against HepG2 and HUVEC cells. It induces apoptosis by reducing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTACBcl-xL degrader-4 markedly inhibits tumor growth in xenograft mouse models.
Product Specifications
CAS Number
2930759-37-6
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (OCCOCCOCCNC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C5NC (=CC (=O) C5=C4) C=6C=CC=C7C=CC=CC76
Molecular Formula
C39H34N4O9
Molecular Weight
702.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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