SOS1-IN-21
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 value of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 activates KRAS by facilitating the conversion of GDP to GTP. SOS1-IN-21 demonstrates potent antiproliferative activity, with IC50 values of 16 nM for NCI-H358 cells and 17 nM for Mia Paca-2 cells. It exhibits significant antitumor activity in Mia Paca-2 xenograft models and is useful for researching KRAS-mutated tumors, such as pancreatic cancer.
Product Specifications
CAS Number
2767633-04-3
Field of Research
Signal Transduction
Smiles
N ([C@H] (C) C1=C (F) C (C (C (C) (C) O) (F) F) =CC=C1) C=2C3=C (C=C (OC) C (OCCOC) =C3) N=C (C) N2
Molecular Formula
C25H30F3N3O4
Molecular Weight
493.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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