12R-LOX-IN-2
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX) . 12R-LOX-IN-2 inhibits imiquimod (IMQ) -induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].
Product Specifications
CAS Number
3026677-37-9
UNSPSC
12352005
Target
DNA/RNA Synthesis; Lipoxygenase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12r-lox-in-2.html
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3
Molecular Formula
C19H13NO
Molecular Weight
271.31
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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