YN14 (mixture of diastereomers)
YN14, a mixture of diastereomers, is a PROTAC (proteolysis-targeting chimera) specifically designed for the KRASG12C protein. It acts as an efficient and selective degrader of KRASG12C, forming a stable KRASG12C:YN14:VHL ternary complex with low binding free energy (ΔG) . YN14 exhibits antiproliferative properties, significantly inhibiting the growth of cancer cells with the KRASG12C mutation.
Product Specifications
CAS Number
3053689-54-3
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1N (C=2C (C (=N1) N3[C@@H] (C) CN (C (C=C) =O) CC3) =CC (F) =C (N2) C4=C (OCC5CCN (CCCC (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=CC=C4F) C9=C (C (C) C) N=CC=C9C
Molecular Formula
C62H75F2N11O7S
Molecular Weight
1156.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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