PROTAC c-Met degrader-5
PROTACc-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader, with a DC50 of 0.42 nM in EBC-1 cells and 0.32 nM in Hs746T cells. It effectively induces apoptosis, causes G1 cell cycle arrest, and inhibits cell migration and invasion. This compound shows strong antiproliferative and degradative effects on c-Met-dependent cancer cells and those resistant to Tepotinib.
Product Specifications
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
42967111 3x 1.0 µg
SAC3D1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
Sign In for Pricing
View Details 
bs-9498R-BF555 100 µL
C9orf153 Polyclonal Antibody, AbBy Fluor™ 555 Conjugated
Sign In for Pricing
View Details MBS2000571-01 24 Strip Well
CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14)
Sign In for Pricing
View Details MBS2000571-02 48 Well
CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14)
Sign In for Pricing
View Details MBS2000571-03 96 Well
CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14)
Sign In for Pricing
View Details MBS2000571-04 5x 96 Well
CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14)
Sign In for Pricing
View Details