Dopamine D3 receptor antagonist-3
Dopamine D3 receptor antagonist-3 is a selective positive allosteric modulator-antagonist (PAM-antagonist) of the D3 dopamine receptor (D3R) that can cross the blood-brain barrier. It demonstrates antagonistic activity in D3R-mediated β-arrestin recruitment assays with an IC50 of 2.5 μM and Kb of 0.49 μM, and in D3R-mediated Go-BRET assays with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 is applicable for the study of neuropsychiatric disorders, including substance use disorders.
Product Specifications
CAS Number
2894793-37-2
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C (C1=C (NC (=C1S (=O) (=O) NC2=CC=C (C (Cl) =C2) C (F) (F) F) C) C) N3CCC (F) (F) C3
Molecular Formula
C18H17ClF5N3O3S
Molecular Weight
485.86
Storage Conditions
-20°C
Notes
For research use only.
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