ROR1-IN-4

ROR1-IN-4 is a selective inhibitor of ROR1 with a dissociation constant (Kd) of 52 nM. It exhibits potent antiproliferative activity in the triple-negative breast cancer (TNBC) cell line MDA-MB-231, with an IC50 of 75 nM. ROR1-IN-4 reduces colony formation, induces apoptosis (apoptosis), and inhibits phosphorylation of ROR1 (Tyr786) in these cells. Additionally, ROR1-IN-4 demonstrates significant antitumor efficacy in nude mice bearing subcutaneous MDA-MB-231 xenograft tumors. This compound is applicable for research related to TNBC.