AG126

AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].

Product Specifications

CAS Number

[118409-62-4]

Product Name Alternative

Tyrphostin AG126

UNSPSC

12352005

Hazard Statement

H301

Target

ERK; Mitosis

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/AG126.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

N#C/C(C#N)=C/C1=CC=C([N+]([O-])=O)C(O)=C1

Molecular Formula

C10H5N3O3

Molecular Weight

215.17

Precautions

H301

References & Citations

[1]Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157 (1) :145-58.|[2]Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5.|[3]Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun;28 (6) :775-88.|[4]Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44 (4) :1722-31.