LCZ960
LCZ960 is an orally active glucokinase (GK) activator that stimulates GK activity in liver cells in vitro and enhances glucose uptake in vivo by activating hepatic GK. It effectively lowers blood glucose levels in diet-induced obesity (DIO) in mice. LCZ960 maintains normal blood sugar and improves glucose tolerance in DIO mice and rats. Additionally, LCZ960 stimulates glycogen synthase flux and increases glycogen turnover in the liver of rats, inducing an increase in hepatic glycogen cycling. This compound is useful for research on obesity and type 2 diabetes induced by high-fat diets.
Product Specifications
CAS Number
1067877-83-1
Field of Research
Metabolism Research
Smiles
N (C ([C@H] (CC1CCCC1) C2=CC=C (S (=O) (=O) N3CCN (C) CC3) C=C2) =O) C=4SC=5C (N4) =CC=C (N5) C=6C=CN=CC6
Molecular Formula
C30H34N6O3S2
Molecular Weight
590.76
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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