XL-3156
XL-3156 is a potent, selective, and cross-species inhibitor of cGAS. It simultaneously occupies allosteric and orthosteric sites, stabilizing the closed conformation of the activation loop to inhibit the interaction and phase separation of cGAS with DNA. XL-3156 is applicable for research into autoimmune diseases and inflammation.
Product Specifications
CAS Number
3117797-30-2
Field of Research
Immunology & Inflammation
Smiles
OC1=C (C (=NN1C2=NC=3C=CC=CC3N2) C) C (C4=NC=CC=C4) C5=C (O) N (N=C5C) C6=NC=7C=CC=CC7N6
Molecular Formula
C28H23N9O2
Molecular Weight
517.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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