Carmaphycin-17
Carmaphycin-17 (CP-17) is a selective proteasome inhibitor with an EC50 of 217 nM. It exhibits potent antimicrobial activity against Trichomonas vaginalis and can overcome resistance to Metronidazole. In mouse models of vaginal trichomoniasis, CP-17 significantly reduces parasite burden after topical treatment without any observed adverse effects. Additionally, Carmaphycin-17 is useful for researching sexually transmitted diseases like trichomoniasis.
Product Specifications
CAS Number
2143080-91-3
Field of Research
Infectious Disease & Virology, Protein Biochemistry
Smiles
C ([C@@H] (C (N[C@H] (C (=O) [C@@]1 (C) CO1) CC2=CC=CC=C2) =O) NC ([C@H] (CC=3C=4C (NC3) =CC=CC4) NC (CCCCC) =O) =O) C=5C=6C (NC5) =CC=CC6
Molecular Formula
C40H45N5O5
Molecular Weight
675.82
Storage Conditions
-20°C
Notes
For research use only.
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