KZR-261
KZR-261 is a Sec61 inhibitor that directly binds to the Sec61 channel, effectively impeding the synthesis of certain Sec61 client proteins. It exhibits broad anti-tumor activity, particularly against colorectal, pancreatic, and prostate cancers, activating the endoplasmic reticulum stress response while showing minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis in H929 cells and effectively suppresses tumor growth in various xenograft mouse models, demonstrating good tolerability.
Product Specifications
CAS Number
2376747-46-3
Field of Research
Cell Biology, Protein Biochemistry
Smiles
C[C@H]1N ([C@H] (C) CN (S (=O) (=O) N2C[C@@H] (C) CN (S (=O) (=O) C3=CC=C (N (C) C) C=C3) CCCN (CC4CCCCC4) CCC2) C1) C5=CC (OC) =CC (F) =C5
Molecular Formula
C38H61FN6O5S2
Molecular Weight
765.06
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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