VS1150
VS1150 (Compound 11) is a phosphorylation-inducing chimeric small molecule (PHICS) designed to target BCR-ABL. It effectively hinders oncogenic kinase BCR-ABL signaling through inhibitory phosphorylation at the Y253 site (EC50: 69 nM), leading to apoptosis. Additionally, VS1150 can inhibit other oncogenic ABL fusion proteins and resistant mutants, such as T315I. This compound is applicable in research on chronic myeloid leukemia (CML) and other cancers driven by ABL fusion proteins.
Product Specifications
CAS Number
2855238-97-8
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NC1=NN (C2=CC=C (Cl) C (Cl) =C2) CC1) C3=CN=C (N=C3C) NCCOCCOCCNC4=NC=C (C (=O) NC5=NN (C6=CC=C (Cl) C (Cl) =C6) CC5) C (=N4) C
Molecular Formula
C36H38Cl4N12O4
Molecular Weight
844.58
Storage Conditions
-20°C
Notes
For research use only.
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