SP3N
SP3N is a specific degrader of the prolyl isomerase (FKBP12) . The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N may be used in research for cancer[1].
Product Specifications
UNSPSC
12352005
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sp3n.html
Smiles
COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C(C(C(C)(C)CC)=O)=O)=O)C3=CC(NC(CCOCCOCCOCCN)=O)=CC=C3)C=C1OC
Molecular Formula
C39H57N3O10
Molecular Weight
727.88
References & Citations
[1]Kagiou C, et al. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation[J]. Nature Communications, 2024, 15 (1) : 5409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
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