RG-239
RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 μM) . It exhibits much higher selectivity for TGR5 over FXRα. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.
Product Specifications
CAS Number
1199222-56-4
Field of Research
Pharmacology & Drug Discovery
Smiles
C (O) (=O) [C@]12[C@@] ([C@@]3 ([C@@] (C) (CC1) [C@@]4 (C) [C@] (CC3) ([C@]5 (C) [C@@] (CC4) (C (C) (C) [C@@] (CC=C) (O) CC5) [H]) [H]) [H]) ([C@H] (C (C) =C) CC2) [H]
Molecular Formula
C33H52O3
Molecular Weight
496.76
Storage Conditions
-20°C
Notes
For research use only.
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