GL64
GL64 is a selective agonist of ADGRD1 with an EC50 of 3.98 μM. It shows low selectivity for the subtypes ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4. GL64 activates ADGRD1 by mimicking the satchel sequence. It regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. Both in vivo and in vitro, GL64 effectively inhibits osteoclastogenesis and prevents bone loss. This compound is suitable for research into osteoclast-related diseases.
Product Specifications
CAS Number
488801-10-1
Field of Research
Metabolism Research
Smiles
O=C1C=2C=CC=CC2NC (C=3C=CC=C (OCC4=CC=C (Cl) C=C4Cl) C3) N1C5=CC=C (Cl) C=C5
Molecular Formula
C27H19Cl3N2O2
Molecular Weight
509.81
Storage Conditions
-20°C
Notes
For research use only.
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